Depend on aHUS Source to get reliable information about atypical hemolytic uremic syndrome (aHUS), a chronic, life-threatening disease.
Treating your patients with aHUS requires a thorough knowledge of this very rare disease. Here you will find current aHUS diagnostic and treatment information, culled from numerous studies.
When it comes to a rare disease as complex as aHUS, getting accurate information is vital for both patients and caregivers. Here you'll get reliable, current information about aHUS and support for managing this difficult disease.
aHUS affects only children
Although aHUS does affect children, almost one-half of people affected are adults 1,2
aHUS is only an acute disease
Due to a permanent genetic mutation, aHUS is an ongoing, lifelong disease of catastrophic systemic, complement-mediated thrombotic microangiopathy (TMA)1,2
aHUS is only a renal (kidney) disease
Renal (Kidney) damage does occur in aHUS patients, but other vital organs, including the heart and brain are affected as well1-4
A genetic mutation needs to be identified to diagnose aHUS
aHUS diagnosis does not require identification of a genetic mutation. Genetic mutation cannot be identified in 30%-50% of patients with aHUS.2 Absence of genetic mutation should not rule out aHUS.
aHUS is safely and effectively treated with plasma exchange/infusion
There have been no well-controlled trials showing plasma exchange to be either safe or effective as aHUS therapy5,6
More information about aHUS: For Healthcare Professionals
More information about aHUS: For Patients & Caregivers
1. Loirat C, Noris M, Fremeaux-Bacchi V. Pediatr Nephrol. 2008;23:1957-1972. 2. Noris M, Caprioli J, Bresin E, et al. Clin J Am Soc Nephrol. 2010;5:1844-1859. 3. Sallée M, Daniel L, Piercecchi MD, et al. Nephrol Dial Transplant. 2010;25:2028-2032. 4. Neuhaus TJ, Calonder S, Leumann EP. Arch Dis Child. 1997;76:518-521. 5. Loirat C, Garnier A, Sellier-Leclerc AL, Kwon T. Semin Thromb Hemost. 2010;36:673-681. 6. Caprioli J, Noris M, Brioschi S, et al; International Registry of Recurrent and Familial HUS/TTP. Blood. 2006;108:1267-1279.
